Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->The effects of hyperprolactinemia on metabolic parameters are not conclusive and a few data evaluating adiponectin levels in prolactinoma and idiopathic hyperprolactinemia exist. The aim of this study is to evaluate effects of hyperprolactinemia on body weight, insulin resistance, β cell function, leptin and adiponectin levels in premenopausal women with hyperprolactinemia.<p cl...

Introduction: The coexistence of hyperthyroidism and thyroid cancer is considered a rare event. We describe a case of papillary carcinoma of the thyroid that mimicked a diffuse toxic goiter.Case report: A 26-year-old female patient presented with a complaint of malaise was diagnosed to have thyrotoxicosis and following the tests performed (sT3: 7.7 (1.7–3.7 ng/dl), sT4: 2.5 (0.7–1.49 ng/dl) TSH: <0.0025 (0.35–4.94...

Aim: Thyroid papillary carcinomas smaller than 1 cm are called papillary microcarcinomas (PMC). They rarely metastasize to lymph node (LN) and distant areas. The presence of palpable lymphadenopathy at the time of diagnosis shows high risk of recurrence regardless of primary tumor size. We aimed to investigate histopathologic characteristics and recurrence frequency of thyroid PMCs with LN metastasis (LNM).Materials and methods: Thyroid PMC cases with LN...

Introduction: Osteogenesis imperfecta (OI) is a congenital, generalized connective tissue disorder characterized by severe osteoporosis and bone fragility. OI is most commonly caused by mutations in genes encoding the α-1 and α-2 chains of type I collagen or proteins involved in posttranslational modification of type I collagen. Although, no controlled studies are done, bisphosphonates are used for the treatment of OI. I.v. bisphosphonates are reported to be more eff...

Introduction: Adrenocortical carcinoma (ACC) is a rare cancer (estimated incidence, 0.7 to 2.0 cases per 1 million population per year) with a poor prognosis. Even after seemingly complete surgical resection, most patients develop recurrence within 5 years. The 5-year survival rate is <15% among patients with metastatic disease.Methods: We present the results of six patients with adrenocortical carcinoma followed in our clinic....

Introduction: Acromegaly is a disease caused by excessive secretion of GH. The cause of acromegaly is GH secreting pituitary adenoam in 99% of the cases. It is estimated that 5% of pituitary adenomas become invasive and may grow to gigantic sizes (>4 cm in diameter). Here, we present a 31 years old acromegalic woman with a delayed diagnosis of a giant invasive pituiatary adenoma.Case report: A 31-year-old woman admitted to our hospital for oligomenor...

Introduction: Vascular endothelial growth factor (VEGF) is a specific mitogen for endothelial cells. Granulocyte–monocyte colony stimulating factor (GM-CSF) is a key player in the regulation of steady-state functions. Studies have shown increased levels of VEGF and GM-CSF in benign and malignant tumors. The aim of this study was to evaluate the relation between VEGF and GM-CSF levels and thyroid nodules >1 cm. and negative for malignancy with fine needle aspiration bi...

Introduction: Psoriasis is a chronic, inflammatory and T-cell mediated autoimmune disease of skin. Its prevalence is 2–3%. It may improve due to immunesupressive effects of hypercortisolaemia during the active phase of Cushing’s syndrome (CS) and may exacerbate after treatment. The aim of this study was to investigate association of psoriasis with CS.Methods: We prospectively followed 62 patients who had been diagnosed with CS between 2010 and ...

Objective: Physical features such as central obesity, purple stria, thin skin, moon face and buffalo hump may be observed in Cushing’s syndrome (CS). Psychiatric and psychological disturbances may also be present in addition to the physical problems. The most common mental disturbance is major depression. Mania and anxiety disorders may also be seen. It may be detected both in active period or in remission of CS on account of persistent effect of previous period of hyperc...

Introduction: Cushing’s syndrome (CS) is accompanied by a ten times increased risk of venous thromboembolism and arterial thrombosis. In this study we aimed to analyze frequency of thromboembolism in CS.Methods: We prospectively followed 62 patients who had been diagnosed with CS between 2010 and 2014 in our clinic. Of the patients, 60% had Cushing’s disease (CD) (29 females and eight males) and 40% had ACTH-independent CS (20 females and five ...